Variation in HIV-1 set-point viral load: Epidemiological analysis and an evolutionary hypothesis
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چکیده
منابع مشابه
Variation in HIV-1 set-point viral load: epidemiological analysis and an evolutionary hypothesis.
The natural course of HIV-1 infection is characterized by a high degree of heterogeneity in viral load, not just within patients over time, but also between patients, especially during the asymptomatic stage of infection. Asymptomatic, or set-point, viral load has been shown to correlate with both decreased time to AIDS and increased infectiousness. The aim of this study is to characterize the ...
متن کاملViral genetic variation accounts for a third of variability in HIV-1 set-point viral load in Europe
HIV-1 set-point viral load-the approximately stable value of viraemia in the first years of chronic infection-is a strong predictor of clinical outcome and is highly variable across infected individuals. To better understand HIV-1 pathogenesis and the evolution of the viral population, we must quantify the heritability of set-point viral load, which is the fraction of variation in this phenotyp...
متن کاملCorrection: Viral genetic variation accounts for a third of variability in HIV-1 set-point viral load in Europe
[This corrects the article DOI: 10.1371/journal.pbio.2001855.].
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OBJECTIVES To examine the relation between symptoms, initial viral load, and viral load set point in primary HIV infection (PHI). DESIGN Prospective cohort of patients with preseroconversion or recent seroconversion HIV infection (typically <60 days) in San Francisco. METHODS Subjects were questioned about 21 potential PHI symptoms at enrollment and were subsequently followed with viral loa...
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Vaccines designed to induce cell-mediated immune responses against human immunodeficiency virus (HIV)-1 are being developed. Such vaccines are unlikely to provide sterilizing immunity but may be associated with reduced viral set points after infection. We modeled the potential impact of a vaccine that reduces viral set point after infection, using natural history data from 311 HIV-1 seroconvert...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2007
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0708559104